Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry.

@article{Yao1994IdentificationOT,
  title={Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry.},
  author={Lena Y Yao and Catherine Moody and Elke Sch{\"o}nherr and Thomas N Wight and Linda j. Sandell},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={1994},
  volume={14 3},
  pages={
          213-25
        }
}
Versican is a large chondroitin sulfate proteoglycan (CSPG) initially identified in cultured human fibroblasts. Previous studies have shown that there is a versican-like molecule in cultured monkey smooth muscle cells. In this study, we have cloned and sequenced the large CSPG from cultured monkey smooth muscle cells, fetal and juvenile monkey aorta, and human fetal aorta. The cDNA sequence from human fetal aorta is completely homologous to the human fibroblast versican. We obtained 2.5 kb of… CONTINUE READING
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