Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha.

@article{Kita2005IdentificationOT,
  title={Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha.},
  author={Atsushi Kita and Hironori Yamasaki and Hironaga Kuwahara and Akie Moriuchi and Keiko Fukushima and Masakazu A R Kobayashi and Tetsuya Fukushima and Ryoko Takahashi and Norio Abiru and Shigeo Uotani and Eiji Kawasaki and Katsumi Eguchi},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={331 2},
  pages={484-90}
}
Adiponectin, an adipose tissue-specific plasma protein, is involved in insulin sensitizing and has anti-atherosclerotic properties. Plasma levels of adiponectin are decreased in obese individuals and patients with type 2 diabetes with insulin resistance. Tumor necrosis factor-alpha (TNF-alpha) decreases the expression of adiponectin in adipocytes. The aims of the present study were: (1) to identify the promoter region responsible for basal transcription of the human adiponectin gene, and (2) to… CONTINUE READING