Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods.

@article{He2015IdentificationOT,
  title={Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods.},
  author={Jia-xuan He and Rong-liang Xue and Siyuan Li and Jianrui Lv and Yong Zhang and Liying Fan and Yun-peng Teng and Haidong Wei},
  journal={International journal of molecular medicine},
  year={2015},
  volume={36 6},
  pages={
          1593-600
        }
}
The present study aimed to explore potential molecular targets and gain further insights into the mechanism of intervertebral disc degeneration (IDD) progression. Microarray datasets of GSE19943, GSE15227 and GSE34095 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in 3 IDD specimens compared with 3 controls in GSE34095, DEGs in 7 grade III and 3 grade IV samples compared with 5 grade II samples in GSE19943, and differentially expressed miRNAs in… 
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Gene expression profile identifies potential biomarkers for human intervertebral disc degeneration
TLDR
Gene Ontology (GO) function enrichment analysis was performed to identify the associated biological functions of DEGs in IDD, which indicated that the DEGs may be involved in various processes, including cell adhesion, biological adhesion and extracellular matrix organization.
Bioinformatics analysis reveals different gene expression patterns in the annulus fibrosis and nucleus pulpous during intervertebral disc degeneration
TLDR
Differences in the expression of BMP2, ESR1 and THBS1 may explain for the pathological differences between AF and NP, and IL6 may have a key role in different degeneration processes in AF andNP.
Upregulated Plant Homeodomain Finger Protein 6 Promotes Extracellular Matrix Degradation in Intervertebral Disc Degeneration Based on Microarray Analysis.
TLDR
Upregulated PHF6 caused IDD by promoting ECM degradation; therefore, PHF 6 could be developed as a potential novel target to prevent the degeneration.
RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs
TLDR
These results provide proof-of-concept for developing novel therapies to combat IVD degeneration through interfering with RIPK1-mediated apoptosis signaling pathways especially in patients withRIPK1 abnormality.
ERRFI1 Inhibits Proliferation and Inflammation of Nucleus Pulposus and is Negatively Regulated by miR-2355-5p in Intervertebral Disc Degeneration.
TLDR
MiR-2355-5p negatively regulated ERFFI1 and prevented the effects of ERRFI1 on inhibiting NP cells proliferation and inflammation and the underlying mechanisms of IVDD.
Decoding the intervertebral disc: Unravelling the complexities of cell phenotypes and pathways associated with degeneration and mechanotransduction.
VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process
TLDR
Increased expression levels of genes involved in alternative vascularization signalling pathways in severely degenerated discs are observed, suggesting that abnormal vascularization is part of the pathological progression of disc degeneration.
Network Pharmacological Dissection of the Mechanisms of Eucommiae Cortex-Achyranthis Radix Combination for Intervertebral Disc Herniation Treatment
TLDR
Pathway enrichment investigation revealed that the EC-AR combination may target IDH-pathology-associated signaling pathways, such as those of cellular senescence and chemokine, neurotrophin, TNF, MAPK, toll-like receptor, and VEGF signaling, to exhibit its therapeutic effects.
Bu‐Shen‐Huo‐Xue‐Fang modulates nucleus pulposus cell proliferation and extracellular matrix remodeling in intervertebral disk degeneration through miR‐483 regulation of Wnt pathway
TLDR
BSHXF, a Chinese traditional medicine formula that contains six Chinese traditional medicinal herbs, is widely used in the treatment of IDD and the function and mechanism of BSHXF in regulating NP cell proliferation and ECM remodeling through the Wnt signaling pathway is demonstrated.
Aucubin inhibits IL‐1β‐ or TNF‐α‐induced extracellular matrix degradation in nucleus pulposus cell through blocking the miR‐140‐5p/CREB1 axis
TLDR
It is suggested that aucubin might ameliorate IL‐1β‐ or TNF‐α‐induced ECM degradation in HNPCs through regulating miR‐140/CREB1.
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