Identification of the peptides that inhibit the function of human monoclonal thyroid-stimulating antibodies from phage-displayed peptide library.

@article{Byun2001IdentificationOT,
  title={Identification of the peptides that inhibit the function of human monoclonal thyroid-stimulating antibodies from phage-displayed peptide library.},
  author={C H Byun and Joong-Yeol Park and Takashi Akamizu and C. B. Chae},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 7},
  pages={3311-8}
}
Autoantibodies against TSH receptor (TSHR) are known to be involved in the occurrence of Graves' disease. It is obvious that mapping of epitopes of the autoantibodies found in the patients with Graves' disease is an important step in elucidating possible mechanism of generation of the autoantibodies against TSHR as well as in developing effective diagnostic and therapeutic approaches for Graves' disease. In this report we have identified the peptide sequences that bind to two human monoclonal… CONTINUE READING