Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities.

@article{Shinde2008IdentificationOT,
  title={Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities.},
  author={Arti V. Shinde and Christopher Bystroff and Chunyu Wang and Mariette G. Vogelezang and Peter A. Vincent and Richard O Hynes and Livingston Van de Water},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 5},
  pages={2858-70}
}
Alternative splicing of the fibronectin (FN) gene transcript provides an efficient mechanism for generating functionally appropriate forms of this adhesive glycoprotein in situ. Cellular FNs that include the EIIIA and/or EIIIB FN-III segments are prominently expressed during embryogenesis, wound healing, tumor progression, and inflammation. However, the roles of this domain in altering overall FN protein structure and regulating cellular function remain unclear. We previously reported that two… CONTINUE READING