Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital

@article{Yoshinari2003IdentificationOT,
  title={Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital},
  author={K. Yoshinari and Kaoru Kobayashi and Rick Moore and T. Kawamoto and M. Negishi},
  journal={FEBS Letters},
  year={2003},
  volume={548}
}
The nuclear receptor CAR, a phenobarbital (PB)‐responsive transcription factor, translocates into the nucleus of hepatocytes after PB induction. In non‐induced mice, CAR forms a physical complex with heat shock protein 90 (HSP90) in the cytoplasm. In response to PB induction, protein phosphatase 2A is recruited to the CAR:HSP90 complex. This recruitment may lead CAR to translocate into the nucleus, consistent with the inhibitions of nuclear CAR accumulation in PB‐induced mouse primary… Expand
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