Identification of the nuclear localization signal of rat liver CTP:phosphocholine cytidylyltransferase.

@article{Wang1995IdentificationOT,
  title={Identification of the nuclear localization signal of rat liver CTP:phosphocholine cytidylyltransferase.},
  author={Yuexi Wang and Jonathon Macdonald and C Condie Kent},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 1},
  pages={
          354-60
        }
}
CTP:phosphocholine cytidylyltransferase (CT) is a major regulatory enzyme in phosphatidylcholine synthesis in mammalian cells. CT is found in both soluble and particulate forms, both of which are nuclear. We report here the identification of a 21-residue sequence at the amino terminus of CT, 8KVNSRKRRKEVPGPNGATEED28, which was sufficient to direct beta-galactosidase into the cell nucleus. Further deletions from either end of this sequence greatly reduced the nuclear localization of beta… CONTINUE READING
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