Identification of the nuclear factor HMG2 as an activator for DFF nuclease activity.

@article{Toh1998IdentificationOT,
  title={Identification of the nuclear factor HMG2 as an activator for DFF nuclease activity.},
  author={Shen Yon Toh and Xiu Jun Wang and Peixiang Li},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={250 3},
  pages={598-601}
}
DNA fragmentation during apoptosis is mediated by a heterodimeric protein complex, DFF45/ICAD and DFF40/CAD/CPAN. Purified DFF40 alone possesses intrinsic nuclease activity that is inhibited by its association with DFF45. The proteolytic cleavage of DFF45 by caspase-3 frees the DFF40 subunit to function as a nuclease. In the course of identifying factors that stimulate DFF activity, we have isolated a nuclear factor and identified it as the high mobility group protein 2 (HMG2). We found that… CONTINUE READING

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