Identification of the novel role of pRB in eye cancer

  title={Identification of the novel role of pRB in eye cancer},
  author={Hong Lai and Fangchao Ma and Shenghan Lai},
  journal={Journal of Cellular Biochemistry},
Cancer of the eye, though relatively rare, can involve multiple areas. Retinoblastoma is the most common primary intraocular cancer in children, with 3–7 cases per million people per year worldwide. Uveal melanoma is the most common primary intraocular cancer in adults, predominately in whites, with annual incidence of six per million people in the United States and Europe. Despite the rarity of retinoblastoma, Knudson's two‐hit hypothesis to explain its genesis was substantiated by elegant… 

Abnormal cell cycle regulation in primary human uveal melanoma cultures

The results indicate that the overexpression of cyclins D1/E and CDKIs p16 and p27, together with a deregulation of the Rb/E2F pathway, may be implicated in the development of human UM.

Diffuse anterior retinoblastoma: current concepts

The most common treatment for diffuse anterior retinoblastoma is enucleation followed by systematic chemotherapy according to the patient’s presentation and clinical course and the challenges of early diagnosis and prospects are discussed.

Radiation Induced Malignancy in Retinoblastoma: New Pathology in a Case Report

This is the first case of a sinonasal adenocarcinoma occurring in the previously irradiated field of the primary tumour and contribute significantly to long term morbidity and mortality rates.

Retinoblastom Yatkinlik Geni ve Retinoblastom

Retinoblastoma tumorsuppressor protein (pRB) controls the G1/S transition in the cell cycle by binding and inactivating E2F transcription factor, which plays a pivotal role in regulating eukaryotic cell cycle progression and apoptosis.

Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approach

Analysis of RB2/p130 methylation status revealed that epigenetic events, most probably consequent to the Exon 1 mutations, determined the observed phenotype in sporadic retinoblastoma, which opens a perspective for new therapeutic approaches.

Management of intraocular retinoblastoma and ocular prognosis

Current management modalities for intraocular retinoblastoma, their indications, and ocular prognosis are reviewed and new treatment modalities are expected.

Copper Alters the Conformation and Transcriptional Activity of the Tumor Suppressor Protein p53 in Human Hep G2 Cells

It is suggested that copper-induced oxidative processes result in the synthesis of mutant p53 with altered transcriptional properties, similar to wild type p53 in the presence of copper and other agents that induce oxidative damage.

Ubiquitin–proteasome system-targeted therapy for uveal melanoma: what is the evidence?

An overview of the crosstalk between UPS and the malignancy of UM is provided, the current UPS-targeted therapies in UM are discussed and its potential in developing novel regimens for UM is highlighted.



Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance.

Demonstration of the prognostic value of the immunohistochemical expression of pRb2/p130 is of significance, even if additional studies are required to confirm these data and to compare the progostic value of p Rb2 / p130 immunodetection to that of other recently proposed markers, such as p53.

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

The finding of abnormalities of the Rb gene in SCLC and pulmonary carcinoids (both neuroendocrine tumors) suggests that this gene may be involved in the pathogenesis of a common adult malignancy.

Altered expression of the retinoblastoma gene product in human sarcomas.

Tumors in which the expression of Rb gene product was decreased were more aggressive than tumors in which this protein was expressed by nearly all cells, suggesting the R b gene product may be an important prognostic variable in patients with these tumors.

p53, bcl-2 and retinoblastoma proteins as long-term prognostic markers in localized carcinoma of the prostate.

PURPOSE The accumulation of p53 and bcl-2 gene products as well as the loss of the retinoblastoma (Rb) gene product have been associated with prostate cancer progression. We assessed whether the

Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors.

Study of superficial transitional cell carcinomas of the urinary bladder by immunohistochemical analysis suggests that alterations of p53 and pRB have a cooperative negative effect on both progression and survival in primary bladder cancer.

p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?

expression of p53 and Rb1 proteins does not appear be useful in determining the prognosis of operable colorectal cancer, although patients with tumours showing aberrant (reduced) R b1 protein expression demonstrated shorter recurrence-free survival and overall survival.

The retinoblastoma gene: a prototypic and multifunctional tumor suppressor.

It is likely that Rb suppresses tumor formation by virtue of its multiple biological activities, and a single protein capable of performing multiple antioncogenic functions may be a common characteristic of other tumor suppressors including p53 and BRCA1/2.

Altered retinoblastoma protein expression in nonsmall cell lung cancer

The authors evaluated the prognostic significance of the loss of Rb protein expression alone, then performed a combined analysis of R b protein and ras p21 status (Rb/ras) as well as an analysis ofRb and p53 protein status ( Rb/p53) in patients with nonsmall cell lung cancer (NSCLC).

Osteosarcoma following retinoblastoma: Age at onset and latency period

Analysis of the age at onset and the latency period of osteosarcoma as the second primary tumor for retinoblastoma with or without subsequent radiotherapy suggests that all or almost all of the patients were genetically predisposed by a mutation of one allele of the RB1 gene.

Frequent disruption of the RB1 pathway in diffuse large B cell lymphoma: prognostic significance of E2F-1 and p16INK4A

The data support a role of E2F-1 as tumour suppressor gene in lymphoma and strongly suggest that the RB1 and p53 pathways are important in the development of de novo DLCL.