Identification of the novel canine CYP1A2 1117 C > T SNP causing protein deletion.

@article{Tenmizu2004IdentificationOT,
  title={Identification of the novel canine CYP1A2 1117 C > T SNP causing protein deletion.},
  author={Daisuke Tenmizu and Yoko Endo and Kiyoshi Noguchi and Hidetaka Kamimura},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2004},
  volume={34 9},
  pages={835-46}
}
The pharmacokinetics of YM-64227 (4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]-pyrimidine-2-(1H)-one), a novel and selective phosphodiesterase type 4 inhibitor, was characterized in beagle dogs. Based on the plasma parent drug to major hydroxylated metabolite ratio, 21 dogs were phenotyped as 16 extensive metabolizers (EM) and five poor metabolizers (PM). Nucleotide sequences of CYPs 1A2, 2B11, 2C21, 2D15, 2E1 and 3A12 were investigated in the EM and PM dogs. A CYP1A2 1117 C>T single nucleotide… CONTINUE READING