Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1.

@article{Koppel2004IdentificationOT,
  title={Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1.},
  author={Estella A. Koppel and Irene Stephanie Ludwig and Marta Hern{\'a}ndez and Todd L Lowary and Rajendrakumar Reddy Gadikota and Alexander B. Tuzikov and Christina M. J. E. Vandenbroucke-Grauls and Yvette van Kooyk and Ben J. Appelmelk and Teunis B H Geijtenbeek},
  journal={Immunobiology},
  year={2004},
  volume={209 1-2},
  pages={117-27}
}
Mycobacterium tuberculosis represents a worldwide health risk and although macrophages are primarily infected, dendritic cells (DC) are important in inducing cellular immune responses against M. tuberculosis. Recent studies have demonstrated that M. tuberculosis targets the DC-specific C-type lectin DC-SIGN to inhibit the immuno-stimulatory function of DC through the interaction of the mycobacterial mannosylated lipoarabinomannan (ManLAM) to DC-SIGN, which prevents DC maturation and induces the… CONTINUE READING