Identification of the minimal tyrosine residues required for linker for activation of T cell function.

@article{Lin2001IdentificationOT,
  title={Identification of the minimal tyrosine residues required for linker for activation of T cell function.},
  author={Jue Lin and Anna Weiss},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 31},
  pages={
          29588-95
        }
}
The linker for activation of T cells (LAT) is essential for signaling through the T cell receptor (TCR). Following TCR stimulation, LAT becomes tyrosine-phosphorylated, creating docking sites for other signaling proteins such as phospholipase C-gamma(1) (PLC-gamma(1)), Grb2, and Gads. In this study, we have attempted to identify the critical tyrosine residues in LAT that mediate TCR activation-induced mobilization of intracellular Ca(2+) and activation of the MAP kinase Erk2. By using the LAT… CONTINUE READING

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