Identification of the miRNA-mRNA regulatory network of small cell osteosarcoma based on RNA-seq

@inproceedings{Xie2017IdentificationOT,
  title={Identification of the miRNA-mRNA regulatory network of small cell osteosarcoma based on RNA-seq},
  author={Lin Xie and Yedan Liao and Lida Shen and Fengdi Hu and Sunlin Yu and Yonghong Zhou and Ya Zhang and Yihao Yang and Dongqi Li and Minyan Ren and Zhongqin Yuan and Zuozhang Yang},
  booktitle={Oncotarget},
  year={2017}
}
Small cell osteosarcoma (SCO) is a rare subtype of osteosarcoma characterized by highly aggressive progression and a poor prognosis. The miRNA and mRNA expression profiles of peripheral blood mononuclear cells (PBMCs) were obtained in 3 patients with SCO and 10 healthy individuals using high-throughput RNA-sequencing. We identified 37 dysregulated miRNAs and 1636 dysregulated mRNAs in patients with SCO compared to the healthy controls. Specifically, the 37 dysregulated miRNAs consisted of 27 up… CONTINUE READING