Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.

@article{Poliseno2010IdentificationOT,
  title={Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.},
  author={Laura Poliseno and L Salmena and Luisa Riccardi and Alessandro Fornari and Min Sup Song and Robin M Hobbs and Paolo Sportoletti and Shorheh Varmeh and Ainara Egia and Giuseppe Fedele and Lucia E. Rameh and Massimo F. Loda and Pier Paolo Pandolfi},
  journal={Science signaling},
  year={2010},
  volume={3 117},
  pages={ra29}
}
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor that antagonizes signaling through the phosphatidylinositol 3-kinase-Akt pathway. We have demonstrated that subtle decreases in PTEN abundance can have critical consequences for tumorigenesis. Here, we used a computational approach to identify miR-22, miR-25, and miR-302 as three PTEN-targeting microRNA (miRNA) families found within nine genomic loci. We showed that miR-22 and the miR-106b~25 cluster are… CONTINUE READING
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