Identification of the melatonin-binding site MT3 as the quinone reductase 2.

  title={Identification of the melatonin-binding site MT3 as the quinone reductase 2.},
  author={Olivier Nosjean and Myriam Ferro and Francis Cog{\'e} and Philippe Beauverger and J M Henlin and François Lefoulon and Jean Luc Fauch{\`e}re and Philippe Delagrange and Emmanuel Canet and Jean A. Boutin},
  journal={The Journal of biological chemistry},
  volume={275 40},
The regulation of the circadian rhythm is relayed from the central nervous system to the periphery by melatonin, a hormone synthesized at night in the pineal gland. Besides two melatonin G-coupled receptors, mt(1) and MT(2), the existence of a novel putative melatonin receptor, MT(3), was hypothesized from the observation of a binding site in both central and peripheral hamster tissues with an original binding profile and a very rapid kinetics of ligand exchange compared with mt(1) and MT(2… CONTINUE READING


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