Identification of the mechanism mediating genioglossus muscle suppression in REM sleep.

@article{Grace2013IdentificationOT,
  title={Identification of the mechanism mediating genioglossus muscle suppression in REM sleep.},
  author={Kevin P Grace and Stuart Wynn Hughes and Richard L Horner},
  journal={American journal of respiratory and critical care medicine},
  year={2013},
  volume={187 3},
  pages={311-9}
}
RATIONALE Inhibition of pharyngeal motoneurons accompanies REM sleep and is a cause of hypoventilation and obstructive sleep apnea in humans. One explanation posits that the neurotransmitters glycine and γ-aminobutyric acid are responsible for REM sleep motor inhibition. However, blockade of that mechanism at cranial motor nuclei increases motor activity in all sleep-wake states, and least of all in REM sleep, arguing against it as a major mechanism of REM sleep pharyngeal motor inhibition… CONTINUE READING