Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets

Abstract

Glucokinase-mediated glucose signaling induces insulin secretion, proliferation, and apoptosis in pancreatic β-cells. However, the precise molecular mechanisms underlying these processes are not clearly understood. Here, we demonstrated that glucokinase activation using a glucokinase activator (GKA) significantly upregulated the expression of Fibulin-5… (More)
DOI: 10.1038/s41598-017-02535-0

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@inproceedings{Okuyama2017IdentificationOT, title={Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets}, author={Tomoko Okuyama and Jun Shirakawa and H. Yanagisawa and Mayu Kyohara and Shunsuke Yamazaki and Kazuki Tajima and Yu Togashi and Yasuo Terauchi}, booktitle={Scientific reports}, year={2017} }