Identification of the major adducts formed by reaction of 5-methylchrysene anti-dihydrodiol-epoxides with DNA in vitro.

@article{Melikian1984IdentificationOT,
  title={Identification of the major adducts formed by reaction of 5-methylchrysene anti-dihydrodiol-epoxides with DNA in vitro.},
  author={A A Melikian and S Amin and Stephen S Hecht and D Hoffmann and J I Pataki and R G Harvey},
  journal={Cancer research},
  year={1984},
  volume={44 6},
  pages={2524-9}
}
  • A A Melikian, S Amin, +3 authors R G Harvey
  • Published 1984 in Cancer research
5-Methylchrysene is metabolically converted to the bay-region dihydrodiol-epoxides, trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (DE-I), in which the methyl group and the epoxide ring are in the same bay region, and trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydro-5-methylchrysene (DE-II). Previous studies have indicated that DE-I is more important in 5-methylchrysene carcinogenesis than is DE-II. Both DE-I and DE-II were individually reacted with calf thymus… CONTINUE READING