Identification of the lipid droplet targeting domain of the Cidea protein[S]

@inproceedings{Christianson2010IdentificationOT,
  title={Identification of the lipid droplet targeting domain of the Cidea protein[S]},
  author={Jennifer L. Christianson and Emilie Boutet and Vishwajeet Puri and Anil Kumar Chawla and M. Czech},
  booktitle={Journal of lipid research},
  year={2010}
}
Cidea, the cell death-inducing DNA fragmentation factor-α-like effector (CIDE) domain-containing protein, is targeted to lipid droplets in mouse adipocytes, where it inhibits triglyceride hydrolysis and promotes lipid storage. In mice, Cidea may prevent lipolysis by binding and shielding lipid droplets from lipase association. Here we demonstrate that human Cidea localizes with lipid droplets in both adipocyte and nonadipocyte cell lines, and we ascribe specific functions to its protein domains… CONTINUE READING