Identification of the ligand-binding site of the BMP type IA receptor for BMP-4.

@article{Hatta2000IdentificationOT,
  title={Identification of the ligand-binding site of the BMP type IA receptor for BMP-4.},
  author={Takeshi I Hatta and Hiroaki Konishi and Etsuko Katoh and Tsugitaka Natsume and Naoto Ueno and Yuji Kobayashi and Toshio Yamazaki},
  journal={Biopolymers},
  year={2000},
  volume={55 5},
  pages={399-406}
}
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta (TGF-beta) superfamily of multifunctional cytokines. BMP induces its signal to regulate growth, differentiation, and apoptosis of various cells upon trimeric complex formation with two distinct type I and type II receptors on the cell surface: both are single-transmembrane serine/threonine kinase receptors. To identify the amino acid residues on BMP type I receptor responsible for its ligand binding, the structure… CONTINUE READING