Identification of the key pathway of oxazolinoanthracyclines mechanism of action in cells derived from human solid tumors.

Abstract

Oxazolinodoxorubicin (O-DOX) and oxazolinodaunorubicin (O-DAU) are novel anthracycline derivatives with a modified daunosamine moiety. In the present study, we evaluated the cytotoxicities, genotoxicities and abilities of O-DOX and O-DAU to induce apoptosis in cancer cell lines (SKOV-3; A549; HepG2), and compared the results with their parent drugs. We… (More)
DOI: 10.1016/j.taap.2016.10.018

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