Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53

@article{Mori2002IdentificationOT,
  title={Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53},
  author={Toshiki Mori and Yoshio Anazawa and Megumi Iiizumi and S. Fukuda and Yusuke Nakamura and H. Arakawa},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={2914-2918}
}
Interferon regulatory factors (IRFs) regulate transcription of interferon genes through DNA sequence-specific binding to these targets. Using a differential display method for examining gene expression in p53-defective cells infected with adenovirus containing wild-type p53, we found that expression of interferon regulatory factor 5 (IRF-5) mRNA was increased in the presence of exogenous p53. An electrophoretic mobility-shift assay showed that a potential p53 binding site (p53BS) detected in… Expand
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