Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

  title={Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.},
  author={Makoto Kobayashi and Ken Itoh and Takafumi Suzuki and Hitoshi Osanai and Keizo Nishikawa and Yasutake Katoh and Yaeko Takagi and Masayuki Yamamoto},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={7 8},
BACKGROUND The transcription factor Nrf2 and its negative regulator Keap1 play important roles in transcriptional induction of a set of detoxifying and anti-oxidant enzymes. To gain an insight into our present enigma as to how cells receive oxidative and electrophilic signals and transduce them to Nrf2, we have developed a zebrafish model system for molecular toxicological studies. RESULTS We systematically cloned zebrafish cytoprotective enzyme cDNAs and found their expression to be… CONTINUE READING
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