Identification of the interaction domains between α- and γ-subunits of GlcNAc-1-phosphotransferase.

Abstract

The disease-associated hexameric N-acetylglucosamine (GlcNAc)-1-phosphotransferase complex (α2 β2 γ2 ) catalyzes the formation of mannose 6-phosphate residues on lysosomal enzymes required for efficient targeting to lysosomes. Using pull-down experiments and mutant subunits, we identified a potential loop-like region in the α-subunits comprising residues… (More)
DOI: 10.1002/1873-3468.12456

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