Identification of the initiation site of poliovirus polyprotein synthesis.

  title={Identification of the initiation site of poliovirus polyprotein synthesis.},
  author={Andrew J. Dorner and Lydia F. Dorner and Glenn R. Larsen and Eckard J Wimmer and Carl W. Anderson},
  journal={Journal of virology},
  volume={42 3},
The complete nucleotide sequence of poliovirus RNA has a long open reading frame capable of encoding the precursor polyprotein NCVP00. The first AUG codon in this reading frame is located 743 nucleotides from the 5' end of the RNA and is preceded by eight AUG codons in all three reading frames. Because all proteins that map at the amino terminus of the polyprotein (P1-1a, VP0, and VP4) are blocked at their amino termini and previous studies of ribosome binding have been inconclusive, direct… CONTINUE READING


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