Identification of the in vivo phosphorylation sites for acidic-directed kinases in murine mdr1b P-glycoprotein.

@article{Glavy1997IdentificationOT,
  title={Identification of the in vivo phosphorylation sites for acidic-directed kinases in murine mdr1b P-glycoprotein.},
  author={Joseph Glavy and Susan Band Horwitz and George A. Orr},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 9},
  pages={
          5909-14
        }
}
  • Joseph Glavy, Susan Band Horwitz, George A. Orr
  • Published in
    The Journal of biological…
    1997
  • Biology, Medicine
  • P-glycoprotein, the multidrug resistance transporter, is phosphorylated in vivo and the major phosphorylation domain has been identified as the linker region (amino acids 629-686). The linker region is a highly charged segment of the transporter in which the negative and positive amino acid side chains are spatially segregated. Both of these charged domains contain several consensus phosphorylation sites for protein kinases. Three of the consensus phosphorylation sites for basic-directed… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 18 CITATIONS

    Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis

    VIEW 3 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    Role of protein kinase CK2 in antitumor drug resistance

    VIEW 2 EXCERPTS
    CITES RESULTS & BACKGROUND

    Effects of the CK2 Inhibitors CX-4945 and CX-5011 on Drug-Resistant Cells

    VIEW 2 EXCERPTS
    CITES BACKGROUND