Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan.

@article{Salv2003IdentificationOT,
  title={Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan.},
  author={Miquel Salv{\`a} and Josep Maria Jansat and Antonio Martinez-Tobed and Jos{\`e} Maria Palacios},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 4},
  pages={404-11}
}
Almotriptan is a novel highly selective 5-hydroxytryptamine(1B/1D) agonist developed for the acute oral treatment of migraine. The in vitro metabolism of almotriptan has been investigated using human liver subcellular fractions and cDNA-expressed human enzymes, to study the metabolic pathways and identify the enzymes responsible for the formation of the… CONTINUE READING