Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.

@article{Kirito2002IdentificationOT,
  title={Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.},
  author={Keita Kirito and Koichi Nakajima and Tomoko Saito Watanabe and Mie Uchida and Masaru Tanaka and Keiya Ozawa and Norio Komatsu},
  journal={Blood},
  year={2002},
  volume={99 1},
  pages={102-10}
}
Signal transducers and activators of transcription (Stat) proteins play important roles in the regulation of hematopoiesis as downstream molecules of cytokine signal transduction. It was previously demonstrated that erythropoietin (EPO), a major regulator of erythropoiesis, activates 3 different Stat members, Stat1, Stat3, and Stat5, in a human EPO-dependent cell line, UT-7/EPO. To clarify the mechanism by which EPO activates Stat1 and Stat3 via the EPO receptor (EPOR), a series of chimeric… CONTINUE READING