Identification of the human c-myc protein nuclear translocation signal.

@article{Dang1988IdentificationOT,
  title={Identification of the human c-myc protein nuclear translocation signal.},
  author={C V Dang and Will W M Lee},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 10},
  pages={4048-54}
}
We identified and characterized two regions of the human c-myc protein that target proteins into the nucleus. Using mutant c-myc proteins and proteins that fuse portions of c-myc to chicken muscle pyruvate kinase, we found that residues 320 to 328 (PAAKRVKLD; peptide M1) induced complete nuclear localization, and their removal from c-myc resulted in mutant proteins that distributed in both the nucleus and cytoplasm but retained rat embryo cell cotransforming activity. Residues 364 to 374… CONTINUE READING