Identification of the heptameric Lsm complex that binds U6 snRNA in Trypanosoma brucei.

  title={Identification of the heptameric Lsm complex that binds U6 snRNA in Trypanosoma brucei.},
  author={Itai Dov Tkacz and Shlomo Cohen and Mali Salmon-Divon and Shulamit Michaeli},
  journal={Molecular and biochemical parasitology},
  volume={160 1},
Lsm proteins are ubiquitous, multifunctional proteins that are involved in nuclear processing and turnover of many RNAs in eukaryotes. Lsm proteins form two distinct complexes, the Lsm2-8 complex, which binds U6 snRNA, and the Lsm1-7 complex, which governs mRNA degradation. Previously, seven Lsm proteins were identified in Trypanosoma brucei. Two of these proteins were later identified as SSm proteins (specific spliceosomal Sm proteins). In this study, the Lsm proteins (Lsm2 and Lsm5) that bind… CONTINUE READING


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