Identification of the haemoglobin scavenger receptor

@article{Kristiansen2001IdentificationOT,
  title={Identification of the haemoglobin scavenger receptor},
  author={Mette Svart Kristiansen and Jonas Heilskov Graversen and Christian Jacobsen and Ole Sonne and Hans J{\"u}rgen Hoffman and S. K. Alex Law and S{\`u}ren K. Moestrup},
  journal={Nature},
  year={2001},
  volume={409},
  pages={198-201}
}
Intravascular haemolysis is a physiological phenomenon as well as a severe pathological complication when accelerated in various autoimmune, infectious (such as malaria) and inherited (such as sickle cell disease) disorders. Haemoglobin released into plasma is captured by the acute phase protein haptoglobin, which is depleted from plasma during elevated haemolysis. Here we report the identification of the acute phase-regulated and signal-inducing macrophage protein, CD163, as a receptor that… 

Haemoglobin scavenger receptor: function in relation to disease.

TLDR
Besides the observation that the haemoglobin scavenger receptor provides a promising target for new treatment possibilities, it offers a novel view on the aetiology of diverse physiological as well as pathophysiological processes.

CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma.

Structure of the haptoglobin–haemoglobin complex

TLDR
This structure reveals that haptoglobin molecules dimerize through an unexpected β-strand swap between two complement control protein (CCP) domains, defining a new fusion CCP domain structure.

Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor.

TLDR
An overview and novel insights into the role of CD163 in Hb redox inactivation and clearance are provided and the nature of chemical modifications introduced onto the Hb molecule and/or oxidative changes induced in the protein appear to influence the extent ofCD163 interaction and cellular uptake.

Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma.

TLDR
SHbSR is an abundant plasma protein potentially valuable in monitoring patients with infections and myelomonocytic leukemia and there are strong indications that HbSR serves an anti-inflammatory function.

Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging.

TLDR
Variant human homologous hemoglobin-binding proteins that collectively may be designated the haptoglobins have diverted from the hapticoglobin gene, contributing to different biologic events that go beyond simple removal from plasma of the toxic hemoglobin.

Association between the Haptoglobin and Heme Oxygenase 1 Genetic Profiles and Soluble CD163 in Susceptibility to and Severity of Human Malaria

TLDR
Increased plasma concentrations of heme, Hp, HO-1, and sCD163 were associated with susceptibility to malaria, which could support the development of targeted therapies and aid in reducing the severity of malaria.

Enhanced expression of haemoglobin scavenger receptor in accumulated macrophages of culprit lesions in acute coronary syndromes.

TLDR
A positive association among intraplaque haemorrhage, enhanced expression of Hb scavenger receptor, and lipid peroxidation in human unstable plaques is suggested.

CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin.

TLDR
It is demonstrated that Hb interacts efficiently with CD163 in the absence of Hp, identifying CD163 as a scavenger receptor for native Hb and small-molecular-weight Hb-based blood substitutes after Hp depletion.

Soluble CD163

  • H. Møller
  • Biology, Medicine
    Scandinavian journal of clinical and laboratory investigation
  • 2012
TLDR
It is now evident that sCD163 is very useful as a biomarker of macrophages activation in various inflammatory diseases, such as macrophage activation syndrome, sepsis, and liver disease, and is a general risk marker of comorbidity and mortality in several chronic inflammatory disease states.
...

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