Identification of the haemoglobin scavenger receptor

@article{Kristiansen2001IdentificationOT,
  title={Identification of the haemoglobin scavenger receptor},
  author={Mette Svart Kristiansen and Jonas Heilskov Graversen and Christian Jacobsen and Ole Sonne and Hans J{\"u}rgen Hoffman and S. K. Alex Law and S{\`u}ren K. Moestrup},
  journal={Nature},
  year={2001},
  volume={409},
  pages={198-201}
}
Intravascular haemolysis is a physiological phenomenon as well as a severe pathological complication when accelerated in various autoimmune, infectious (such as malaria) and inherited (such as sickle cell disease) disorders. Haemoglobin released into plasma is captured by the acute phase protein haptoglobin, which is depleted from plasma during elevated haemolysis. Here we report the identification of the acute phase-regulated and signal-inducing macrophage protein, CD163, as a receptor that… 
CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma.
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An overview and novel insights into the role of CD163 in Hb redox inactivation and clearance are provided and the nature of chemical modifications introduced onto the Hb molecule and/or oxidative changes induced in the protein appear to influence the extent ofCD163 interaction and cellular uptake.
Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma.
TLDR
SHbSR is an abundant plasma protein potentially valuable in monitoring patients with infections and myelomonocytic leukemia and there are strong indications that HbSR serves an anti-inflammatory function.
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A positive association among intraplaque haemorrhage, enhanced expression of Hb scavenger receptor, and lipid peroxidation in human unstable plaques is suggested.
CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin.
TLDR
It is demonstrated that Hb interacts efficiently with CD163 in the absence of Hp, identifying CD163 as a scavenger receptor for native Hb and small-molecular-weight Hb-based blood substitutes after Hp depletion.
Induction of the CD163‐dependent haemoglobin uptake by macrophages as a novel anti‐inflammatory action of glucocorticoids
TLDR
It is shown that dexamethasone strongly induced the specific uptake of haemoglobin–haptoglobin complexes, CD163 mRNA transcription and cell surface expression by human macrophages, and proposed the augmentation of Hb clearance as a novel anti‐inflammatory action of glucocorticoids.
Soluble CD163
  • H. Møller
  • Biology, Medicine
    Scandinavian journal of clinical and laboratory investigation
  • 2012
TLDR
It is now evident that sCD163 is very useful as a biomarker of macrophages activation in various inflammatory diseases, such as macrophage activation syndrome, sepsis, and liver disease, and is a general risk marker of comorbidity and mortality in several chronic inflammatory disease states.
Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes
TLDR
The haptoglobin-dependent HbSR/CD163 scavenging system for hemoglobin clearance prevents toxic effects of hemoglobin in plasma and kidney and explains the decrease in the haptoxide plasma concentration in patients with accelerated hemolysis.
CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response
TLDR
Recent data indicate that solubleCD163 may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions and a role for soluble CD163 in immune suppression has been proposed.
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