Identification of the haematopoietic stem cell niche and control of the niche size

@article{Zhang2003IdentificationOT,
  title={Identification of the haematopoietic stem cell niche and control of the niche size},
  author={Jiwang Zhang and Chao Niu and L Ye and Haiyang Huang and Xi C. He and Weichao Tong and Jason Ross and Jeff S. Haug and Teri J. Johnson and Jian Feng and Stephen Harris and Leanne M Wiedemann and Yuji Mishina and Linheng Li},
  journal={Nature},
  year={2003},
  volume={425},
  pages={836-841}
}
Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential). However, the HSC ‘niche’—the in vivo regulatory microenvironment where HSCs reside—and the mechanisms involved in controlling the number of adult HSCs remain largely unknown. The bone morphogenetic protein (BMP) signal has an essential role in inducing haematopoietic tissue during embryogenesis. We investigated the roles of the BMP… CONTINUE READING
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