Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.

@article{Matsuzaka2002IdentificationOT,
  title={Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.},
  author={Yasunari Matsuzaka and Koichi Okamoto and Hitomi Tsuji and Tomotaka Mabuchi and Akira Ozawa and Gen Tamiya and Hidetoshi Inoko},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={297 5},
  pages={
          1171-80
        }
}
To identify novel psoriasis-associated genes, we focused on several ESTs (expressed sequence tags) whose expression was predominantly increased in the affected skin in patients with psoriasis vulgaris, as assessed by microarray assay. In this paper, a full-length cDNA corresponding to one of those ESTs (AI440266) was isolated by screening of cultured human keratinocyte cDNA libraries. This cDNA has an open reading frame of a 309-amino-acid protein, sharing significant homology to one of the… CONTINUE READING

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