Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2.

@article{Luongo2000IdentificationOT,
  title={Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2.},
  author={Cindy L. Luongo and Karin M Reinisch and Stephen C Harrison and Max L Nibert},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 4},
  pages={2804-10}
}
The 144-kDa lambda2 protein of mammalian reovirus catalyzes a number of enzymatic activities in the capping of reovirus mRNA, including the transfer of GMP from GTP to the 5' end of the 5'-diphosphorylated nascent transcript. This reaction proceeds through a covalently autoguanylylated lambda2-GMP intermediate. The smaller size of RNA capping guanylyltransferases from other organisms suggested that the lambda2-associated guanylyltransferase would be only a part of this protein. Limited… CONTINUE READING
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