Identification of the glomerular podocyte as a target for growth hormone action.

@article{Reddy2007IdentificationOT,
  title={Identification of the glomerular podocyte as a target for growth hormone action.},
  author={Gv Ramachandra Reddy and Mary J Pushpanathan and Richard F. Ransom and Lawrence B. Holzman and Frank C. Brosius and Maria Diakonova and Peter William. Mathieson and M. Kamran Saleem and Edward O. List and John J. Kopchick and Stuart J. Frank and Ram K. Menon},
  journal={Endocrinology},
  year={2007},
  volume={148 5},
  pages={
          2045-55
        }
}
GH excess in both the human and transgenic animal models is characterized by significant changes in blood pressure and renal function. The GH/GH receptor (GHR) axis is also implicated in the development of diabetic nephropathy. However, it is not clear whether GH's actions on renal function are due to indirect actions mediated via changes in blood pressure and vascular tone or due to direct action of GH on the kidney. We hypothesized that functional GHRs are expressed on the glomerular podocyte… CONTINUE READING
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