Identification of the gene that codes for the σ2 receptor

@article{Alon2017IdentificationOT,
  title={Identification of the gene that codes for the $\sigma$2 receptor},
  author={A. Alon and H. Schmidt and Michael D. Wood and James J. Sahn and Stephen F Martin and A. Kruse},
  journal={Proceedings of the National Academy of Sciences},
  year={2017},
  volume={114},
  pages={7160 - 7165}
}
Significance Of the many receptors that were pharmacologically described during the 20th century, almost all were cloned by the end of the 1990s. A key exception is the σ2 receptor, a potential therapeutic target for diseases as diverse as schizophrenia, Alzheimer’s disease, and cancer. Despite the development of a rich pharmacopeia, the unknown molecular identity of the receptor has crippled biological investigation. Here, we identify the σ2 receptor as TMEM97, a membrane protein implicated in… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Crystal structure of the human σ1 receptor
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor.
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site
The σ2 receptor: a novel protein for the imaging and treatment of cancer.
Biochemical Pharmacology of the Sigma-1 Receptor
TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease
Sigma-2 receptors as a biomarker of proliferation in solid tumours
Purification, molecular cloning, and expression of the mammalian sigma1-binding site.
Sigma Receptor Binding Assays
  • U. Chu, A. Ruoho
  • Chemistry, Medicine
  • Current protocols in pharmacology
  • 2015
...
1
2
3
4
5
...