Identification of the gene (lgtG) encoding the lipooligosaccharide beta chain synthesizing glucosyl transferase from Neisseria gonorrhoeae.

@article{Banerjee1998IdentificationOT,
  title={Identification of the gene (lgtG) encoding the lipooligosaccharide beta chain synthesizing glucosyl transferase from Neisseria gonorrhoeae.},
  author={Anamika Banerjee and Rong Wang and Sacha N Uljon and Phoebe A Rice and Emil C. Gotschlich and D. C. Stein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 18},
  pages={10872-7}
}
The lipooligosaccharide from Neisseria gonorrhoeae (GC), consists of lipid A, an oligosaccharide core and three branches, alpha, beta, and gamma. We report the cloning of the gene (lgtG, lipooligosaccharide glycosyl transferase G) encoding the glucosyl transferase of GC that initiates the beta chain which consists of a lactosyl moiety. This gene contains a homopolymeric tract of cytidine [poly(C)] and we demonstrate that changes in the number of Cs in poly(C) account for the variation of beta… CONTINUE READING