Identification of the functional initiation codons of a phase-variable gene of Haemophilus influenzae, lic2A, with the potential for differential expression.

@article{Dixon2007IdentificationOT,
  title={Identification of the functional initiation codons of a phase-variable gene of Haemophilus influenzae, lic2A, with the potential for differential expression.},
  author={Kevin Dixon and Christopher D Bayliss and Katherine M Makepeace and E . Richard Moxon and Derek W Hood},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 2},
  pages={511-21}
}
Simple sequence repeats located within reading frames mediate phase-variable ON/OFF switches in gene expression by generating frameshifts. Multiple translation initiation codons in different reading frames are found upstream of most Haemophilus influenzae tetranucleotide repeat tracts, raising the possibility of multiple active reading frames and more than two levels of gene expression for these loci. Phase variation between three levels of gene expression (strong, weak, and none) was observed… CONTINUE READING