Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

Abstract

DNA interstrand crosslink (ICL) repair (ICLR) has been implicated in the resistance of cancer cells to ICL-inducing chemotherapeutic agents. Despite the clinical significance of ICL-inducing chemotherapy, few studies have focused on developing small-molecule inhibitors for ICLR. The mammalian DNA polymerase ζ, which comprises the catalytic subunit REV3L and… (More)
DOI: 10.1016/j.bmc.2016.07.026

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Cite this paper

@article{Actis2016IdentificationOT, title={Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.}, author={Marcelo L Actis and Nigus D. Ambaye and Benjamin J Evison and Youming Shao and Murugendra S. Vanarotti and Akira Inoue and Ezelle T McDonald and Sotaro Kikuchi and Richard J. Heath and Kodai Hara and Hiroshi Hashimoto and Naoaki Fujii}, journal={Bioorganic & medicinal chemistry}, year={2016}, volume={24 18}, pages={4339-4346} }