Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation.

@article{Clark2017IdentificationOT,
  title={Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation.},
  author={Stewart D. Clark and Terrence P. Kenakin and Steven Gertz and C. Hassler and Elaine A. Gay and Tiffany L Langston and Rainer K Reinscheid and Scott P. Runyon},
  journal={Neuropharmacology},
  year={2017},
  volume={118},
  pages={
          69-78
        }
}
The neuropeptide S system has been implicated in a number of centrally mediated behaviors including memory consolidation, anxiolysis, and increased locomotor activity. Characterization of these behaviors has been primarily accomplished using the endogenous 20AA peptide (NPS) that demonstrates relatively equal potency for the calcium mobilization and cAMP second messenger pathways at human and rodent NPS receptors. This study is the first to demonstrate that truncations of the NPS peptide… CONTINUE READING