Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.

@article{Villani2004IdentificationOT,
  title={Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.},
  author={Maria Grazia Villani and Valentina Appierto and Elena Cavadini and Manuela Valsecchi and Sandro Sonnino and Robert W. Curley and Franca Formelli},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 18 Pt 1},
  pages={6265-75}
}
PURPOSE The synthetic retinoid fenretinide (4-HPR) exhibits preventive and therapeutic activity against ovarian tumors. An unidentified polar metabolite was previously found in 4-HPR-treated subjects and in A2780 human ovarian carcinoma cells continuously treated with 4-HPR (A2780/HPR). The metabolite and the enzyme involved in its formation in tumor cells are herein identified. EXPERIMENTAL DESIGN The metabolite was identified by mass spectrometry in A2780/HPR cell extracts and in plasma… CONTINUE READING
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