Identification of the fatty acid activation site on human ClC-2.


Fatty acids (including lubiprostone and cobiprostone) are human ClC-2 (hClC-2) Cl- channel activators. Molecular and cellular mechanisms underlying this activation were examined. Role of a four-amino acid PKA activation site, RGET691, of hClC-2 was investigated using wild-type (WT) and mutant (AGET, RGEA, and AGAA) hClC-2 expressed in 293EBNA cells as well… (More)
DOI: 10.1152/ajpcell.00267.2016


Cite this paper

@article{Cuppoletti2017IdentificationOT, title={Identification of the fatty acid activation site on human ClC-2.}, author={John Cuppoletti and Kirti P. Tewari and Jayati Chakrabarti and Danuta H. Malinowska}, journal={American journal of physiology. Cell physiology}, year={2017}, volume={312 6}, pages={C707-C723} }