Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs.


tRNAs from all three kingdoms of life contain a variety of modified nucleotides required for their stability, proper folding, and accurate decoding. One prominent example is the eponymous ribothymidine (rT) modification at position 54 in the T-arm of eukaryotic and bacterial tRNAs. In contrast, in most archaea this position is occupied by another… (More)
DOI: 10.1261/rna.028498.111


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