Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.

@article{Hwang1991IdentificationOT,
  title={Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.},
  author={Shirley S Hwang and T. H. Boyle and H Kim Lyerly and Bryan R Cullen},
  journal={Science},
  year={1991},
  volume={253 5015},
  pages={71-4}
}
Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line--tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal… CONTINUE READING