Identification of the endophilins ( SH 3 p 4 y p 8 y p 13 ) as novel binding partners for the b 1-adrenergic receptor

  title={Identification of the endophilins ( SH 3 p 4 y p 8 y p 13 ) as novel binding partners for the b 1-adrenergic receptor},
  author={Yuting Tang and Liaoyuan A. Hu and William E Miller and Niels Ringstad and Randy A Hall and Julie A. Pitcher and Pietro DeCamilli and Robert J Lefkowitz},
Several G-protein coupled receptors, such as the b1-adrenergic receptor (b1-AR), contain polyproline motifs within their intracellular domains. Such motifs in other proteins are known to mediate protein–protein interactions such as with Src homology (SH)3 domains. Accordingly, we used the proline-rich third intracellular loop of the b1-AR either as a glutathione S-transferase fusion protein in biochemical ‘‘pull-down’’ assays or as bait in the yeast two-hybrid system to search for interacting… CONTINUE READING


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