Identification of the earliest B lineage stage in mouse bone marrow.

  title={Identification of the earliest B lineage stage in mouse bone marrow.},
  author={Y. Li and R. Wasserman and K. Hayakawa and R. Hardy},
  volume={5 6},
  • Y. Li, R. Wasserman, +1 author R. Hardy
  • Published 1996
  • Biology, Medicine
  • Immunity
  • We have identified a very early stage of B lineage cells in the CD45R (B220)+CD24 (HSA) pre-pro-B fraction of mouse bone marrow delineated by expression of AA4.1, a molecule found on stem cells and early B lineage cells. These cells are B lineage precursors based on their capacity to generate B lineage cells rapidly in stromal-dependent culture and their expression of high levels of germline IgH transcripts in the absence of Rag-1/2. Half of these AA4.1+ precursors express low levels of CD4… CONTINUE READING
    416 Citations
    Lineage specification and plasticity in CD19− early B cell precursors
    • 207
    • PDF
    Fates of human B-cell precursors.
    • 252
    The Earliest Step in B Lineage Differentiation from Common Lymphoid Progenitors Is Critically Dependent upon Interleukin 7
    • 208
    • PDF
    Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.
    • 149
    • PDF
    Identification of a germ-line pro-B cell subset that distinguishes the fetal/neonatal from the adult B cell development pathway
    • 28
    • PDF