Identification of the earliest B lineage stage in mouse bone marrow.

@article{Li1996IdentificationOT,
  title={Identification of the earliest B lineage stage in mouse bone marrow.},
  author={Y. Li and R. Wasserman and K. Hayakawa and R. Hardy},
  journal={Immunity},
  year={1996},
  volume={5 6},
  pages={
          527-35
        }
}
  • Y. Li, R. Wasserman, +1 author R. Hardy
  • Published 1996
  • Biology, Medicine
  • Immunity
  • We have identified a very early stage of B lineage cells in the CD45R (B220)+CD24 (HSA) pre-pro-B fraction of mouse bone marrow delineated by expression of AA4.1, a molecule found on stem cells and early B lineage cells. These cells are B lineage precursors based on their capacity to generate B lineage cells rapidly in stromal-dependent culture and their expression of high levels of germline IgH transcripts in the absence of Rag-1/2. Half of these AA4.1+ precursors express low levels of CD4… CONTINUE READING
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