Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.

@article{Patel1992IdentificationOT,
  title={Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.},
  author={Rekha C Patel and Ganes C Sen},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 11},
  pages={
          7671-6
        }
}
The interferon-inducible double-stranded (ds) RNA-activated protein kinase (p68 kinase) is a physiologically important enzyme that regulates the rate of cellular and viral protein synthesis by phosphorylating and thereby inactivating the peptide chain initiation factor 2. We have generated a cDNA clone of the human p68 kinase by polymerase chain reaction cloning using the recently published sequence of this enzyme. Active enzyme was synthesized by in vitro transcription-translation of the cDNA… CONTINUE READING

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