Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex.

@article{Brown2007IdentificationOT,
  title={Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex.},
  author={Alistair K. Brown and Apoorva Bhatt and Albel Singh and Elesh Saparia and Alex F Evans and Gurdyal S Besra},
  journal={Microbiology},
  year={2007},
  volume={153 Pt 12},
  pages={4166-73}
}
Mycolic acids are vital components of the Mycobacterium tuberculosis cell wall and are essential for survival. While most components of the fatty acid synthase-II (FAS-II) enzymic machinery that synthesizes these long chain alpha-alkyl, beta-hydroxy fatty acids have been identified, the gene encoding the beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase activity has remained elusive. Recent bioinformatics-based studies and drug inhibition experiments have identified the M. tuberculosis… CONTINUE READING