Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver

@article{Fabrizi1999IdentificationOT,
  title={Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver},
  author={L. Fabrizi and S. Gemma and E. Testai and L. Vittozzi},
  journal={Journal of Biochemical and Molecular Toxicology},
  year={1999},
  volume={13}
}
The metabolism of diazinon, an organophosphorothionate pesticide, to diazoxon and pyrimidinol has been studied in incubations with hepatic microsomes from control Sprague–Dawley (SD) rats or SD rats treated with different P450‐specific inducers (phenobarbital, dexamethasone, β‐napthoflavone, and pyrazole). 
Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes.
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Downregulation of male-specific cytochrome P450 by profenofos.
In vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide.
Diazinon is activated by CYP2C19 in human liver.
An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes
  • K. Abass, M. Turpeinen, O. Pelkonen
  • Chemistry, Medicine
  • Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
  • 2009
In vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon.
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