Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil.


AIMS To characterize the cytochrome P450 (CYP) enzymes responsible for the N-demethylation of sildenafil to its main metabolite, UK-103 320, to investigate the potential inhibitory effects of sildenafil on CYP enzymes and to evaluate the potential of selected drugs to affect sildenafil metabolism. METHODS The metabolic pathways of sildenafil N… (More)